Tyrosinase (Melanoma Marker) Antibody
Product Sizes
20 ug
£364.00
7299-MSM1-P0-20UG
About this Product
- SKU:
- 7299-MSM1-P0
- Additional Names:
- LB24-AB | Monophenol monooxygenase | SK29-AB | Tumor rejection antigen AB
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry
- translate.label.attr.clone:
- T311
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a cluster of proteins between 70-80kDa; identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1; TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3;4-dihydroxy-phenylalanine (dopa); and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
- Host:
- Mouse
- Immunogen:
- Recombinant tyrosinase protein
- Isotype:
- IgG2a
- Molecular Weight:
- 70-80kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122555
