Recombinant Thymidylate Synthase (5-FU Resistance Marker) Antibody

Product Sizes

100 ug

£671.00

7298-RBM7-P1-100UG

About this Product

SKU:: 7298-RBM7-P1
Application:: Immunohistochemistry, Western Blot
translate.label.attr.clone:: TYMS/9091R
Clonality:: Monoclonal
Extra Details:: It recognizes a protein of 36kDa; identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP); which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines; an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5;10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal; gastric; head and neck; and breast carcinomas.
Host:: Rabbit
Immunogen:: Recombinant human thymidylate synthase protein fragment (around aa 1-200) (exact sequence is proprietary)
Isotype:: IgG
Molecular Weight:: 36kDa
Research Area:: Cardiovascular
Shipping Conditions:: Blue Ice
Storage Conditions:: Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months.;Non-hazardous. No MSDS required.
Supplier:: NeoBiotechnologies
Type:: Antibodies: Monoclonal Antibody

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