Recombinant Thymidylate Synthase (5-FU Resistance Marker) Antibody
Product Sizes
20 ug
£364.00
7298-RBM7-P0-20UG
About this Product
- SKU:
- 7298-RBM7-P0
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- TYMS/9091R
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a protein of 36kDa; identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP); which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines; an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5;10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal; gastric; head and neck; and breast carcinomas.
- Host:
- Rabbit
- Immunogen:
- Recombinant human thymidylate synthase protein fragment (around aa 1-200) (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 36kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months.;Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135755
