TRPC6 / Transient Receptor Potential Cation Channel Subfamily C Member 6 Antibody
Product Sizes
100 ug
£671.00
7225-MSM1-P1-100UG
About this Product
- SKU:
- 7225-MSM1-P1
- Additional Names:
- Transient receptor protein 6
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- TRPC6/7671
- Clonality:
- Monoclonal
- Extra Details:
- Phenylalanine hydroxylase (PAH); tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH; TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom; which is bound to two histidines and a glutamate; and is likely to be involved in the formation of the hydroxylating intermediate. TPH is both the first and rate-limiting-step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin; including depression; aggression; alcoholism and schizophrenia. For instance; LDOPA; which is used as a common therapy for Parkinson s disease (PD) patients; inhibits TPH function which; subsequently; is thought to contribute to the onset of depression in PD patients.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TRPC6 protein
- Isotype:
- IgG2
- Molecular Weight:
- 50.9kDa
- Research Area:
- Developmental Biology; Neuroscience; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=132024
