TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) Antibody
Product Sizes
100 ug
£671.00
7185-MSM4-P1ABX-100UG
About this Product
- SKU:
- 7185-MSM4-P1ABX
- Additional Names:
- Epstein-Barr virus-induced protein 6
- Application:
- ELISA
- translate.label.attr.clone:
- TRAF1/3299
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes a protein of 52kDa; which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically; histopathologically; immunopathologically and genetically; they differ considerably in their prognosis. In particular; common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However; both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously; whereas those of cALCL persist and may progress and spread. Moreover; LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach; in contrast to patients with cALCL. Besides; LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1); a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression; tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human TRAF1 protein (around aa 73-219) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 52kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Dendritic Cell Marker; Lung Cancer; Nuclear Marker; Ovarian Cancer; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=127176
