Complement 3d (C3d) (Acute Humoral Rejection Marker) Antibody
Product Sizes
20 ug
£364.00
718-MSM1-P0-20UG
About this Product
- SKU:
- 718-MSM1-P0
- Additional Names:
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- C3D/2891
- Clonality:
- Monoclonal
- Extra Details:
- The complement component proteins; C2; C3; C4 and C5; are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors; C3aR; C1R and C5aR; induces proinflammatory events; such as cellular degranulation; smooth muscle contraction; arachidonic acid metabolism; cytokine release; leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype; high-affinity and memory humoral immune responses to T-dependent foreign antigens; as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 1250-1450) of human C3 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 35kDa (predicted)
- Research Area:
- Cardiovascular; Complement System; Immunology; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122433
