Recombinant TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody
Product Sizes
20 ug
£364.00
7173-RBM16-P0-20UG
About this Product
- SKU:
- 7173-RBM16-P0
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- TPO/6417R
- Clonality:
- Monoclonal
- Extra Details:
- Thyroperoxidase (TPO) is a 933 amino acid; type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones; thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis; including congenital hypothyroidism; congenital goiter; and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment of human TPO (around aa 685-804) (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 100kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122407
