Tropomyosin; alpha-1 chain (striated muscle) Antibody
Product Sizes
100 ug
£671.00
7168-MSM1-P1-100UG
About this Product
- SKU:
- 7168-MSM1-P1
- Additional Names:
- Alpha-tropomyosin | Tropomyosin-1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- TPM1/4510
- Clonality:
- Monoclonal
- Extra Details:
- Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells; both muscle and non-muscle; where they bind actin filaments and function to modulate Actin-myosin interaction and stabilize actin filament structure. Tropomyosin α is encoded by the TPM1 gene; which maps to human chromosome 15q22.2 and undergoes alternative splicing to generate at least four isoforms; including skeletal muscle (isoform 1); smooth muscle (isoform 2); fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin b is encoded by the TPM2 gene; which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms; including skeletal muscle (isoform 1); non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3). Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with actin filaments may increase the rigidity of actin filaments. Tropomyosin also interacts with caldesmon to regulate smooth muscle contraction.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length TPM1 protein
- Isotype:
- IgG1
- Molecular Weight:
- 35-45kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=132023
