Recombinant p53 (Tumor Suppressor Protein) Antibody
Product Sizes
20 ug
£364.00
7157-MSM21-P0-20UG
About this Product
- SKU:
- 7157-MSM21-P0
- Additional Names:
- Antigen NY-CO-13 | Phosphoprotein p53 | Tumor suppressor p53
- Application:
- Flow Cytometry, Western Blot
- translate.label.attr.clone:
- rTP53/3780
- Clonality:
- Monoclonal
- Extra Details:
- The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array; containing more than 19;000; full-length human proteins. Recognizes a 53kDa protein; which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth; replication; and apoptosis. It binds to MDM2; SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma; lung carcinoma; colorectal; and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors; including breast; ovarian; bladder; colon; lung; and melanoma.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length TP53 protein
- Isotype:
- IgG1
- Molecular Weight:
- 53kDa
- Research Area:
- AKT Signaling; Bladder Cancer; Breast Cancer; Cardiovascular; Colon Cancer; Cytokine Signaling; Defective Intrinsic Apoptosis; Immunology; Infectious Disease; Lung Cancer; MAPK Signaling; Nuclear Mark
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=152504
