Recombinant p53 Tumor Suppressor Protein Antibody
Product Sizes
100 ug
£671.00
7157-MSM18-P1-100UG
About this Product
- SKU:
- 7157-MSM18-P1
- Additional Names:
- Antigen NY-CO-13 | Phosphoprotein p53 | Tumor suppressor p53
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- rBP53-12
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line; such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells; principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus; but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma; lung carcinoma; colorectal; and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.
- Host:
- Mouse
- Immunogen:
- Recombinant human wild-type p53 protein
- Isotype:
- IgG1
- Molecular Weight:
- 53kDa.
- Research Area:
- AKT Signaling; Apoptosis; Bladder Cancer; Breast Cancer; Cancer; Cardiovascular; Colon Cancer; Cytokine Signaling; Defective Intrinsic Apoptosis; Hypoxia; Immunology; Infectious Disease; Lung Cancer;
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122285
