Recombinant Topoisomerase II alpha (Proliferation & Drug-Resistance Marker) Antibody
Product Sizes
20 ug
£364.00
7153-MSM11-P0-20UG
About this Product
- SKU:
- 7153-MSM11-P0
- Additional Names:
- DNA topoisomerase II; alpha isozyme
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- rTOP2A/8339
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a 170kDa protein; which is identified as topoisomerase IIα. It shows no cross-reaction with Topoisomerase II β or I. Topo II α plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-; G2- & M-phases in transformed and developmentally regulated normal cells. Topo II α is also implicated in drug resistance of tumor cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topo IIa is the predominant mechanism of resistance to several chemotherapeutic agents.
- Host:
- Mouse
- Immunogen:
- Recombinant human Topoisomerase II alpha fragment (aa1300-1500) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 170kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131968
