C1QB / Complement C1q B-Chain Antibody
Product Sizes
20 ug
£364.00
713-MSM2-P0-20UG
About this Product
- SKU:
- 713-MSM2-P0
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- C1QB/2962
- Clonality:
- Monoclonal
- Extra Details:
- C1q; a subcomponent of the classical complement pathway; is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B; while three of these subunits; designated C1q-A through C1q-C; are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity; which may be antibody-dependent or independent. Macrophages are the primary source of C1q; while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 41-188) of human C1QB protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 26-29kDa
- Research Area:
- Complement System; Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122226
