A20 / TNFAIP3 (Marker of Tamoxifen Resistance) Antibody
Product Sizes
100 ug
£671.00
7128-MSM3-P1ABX-100UG
About this Product
- SKU:
- 7128-MSM3-P1ABX
- Additional Names:
- OTU domain-containing protein 7C | Putative DNA-binding protein A20 | Zinc finger protein A20
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- TNFAIP3/2813
- Clonality:
- Monoclonal
- Extra Details:
- A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities; is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. HighA20expression levels were observed in more aggressive breast tumors (ER-negative; progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 241-356) of human TNFAIP3 protein (exact sequence is proprietary)
- Isotype:
- IgG2c
- Molecular Weight:
- ~90kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Immunology; Ovarian Cancer; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122224
