TNF-alpha (Tumor Necrosis Factor alpha) Antibody
Product Sizes
20 ug
£364.00
7124-MSM7-P0-20UG
About this Product
- SKU:
- 7124-MSM7-P0
- Additional Names:
- Cachectin | TNF-alpha | Tumor necrosis factor ligand superfamily member 2
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- MAb1
- Clonality:
- Monoclonal
- Extra Details:
- This MAb recognizes human 17-26kDa protein; which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule; or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages; and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two; three; or five non-covalently linked units; but shows a single 17kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25kDa protein Tumor Necrosis Factor beta (lymphotoxin); sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells; being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells; TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines; activating polymorphonuclear neutrophils and osteoclasts; and induction of interleukin 1; prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
- Host:
- Mouse
- Immunogen:
- Recombinant human TNF-alpha
- Isotype:
- IgM
- Molecular Weight:
- 17kDa
- Research Area:
- AKT Signaling; Apoptosis; Autophagy; Cardiovascular; Colon Cancer; Cytokine Signaling; Developmental Biology; Hematopoietic Stem Cells; Immunology; MAPK Signaling; Neuroinflammation; Ovarian Cancer; S
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122221
