Recombinant TIA1 (T-Cell-Restricted Intracellular Antigen-1) Antibody
Product Sizes
100 ug
£671.00
7072-RBM2-P1-100UG
About this Product
- SKU:
- 7072-RBM2-P1
- Additional Names:
- Nucleolysin TIA-1 isoform p40 | RNA-binding protein TIA-1 | T-cell-restricted intracellular antigen-1 | p40-TIA-1
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- TIA1/1352R
- Clonality:
- Monoclonal
- Extra Details:
- The T cell intracellular antigen 1 (TIA 1) is a 17 kDa cytoplasmic granule associated protein also designated as GMP 17; for granule membrane protein of 17 kDa. The GMP 17/TIA 1 molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) mediated apoptosis. Within hematopoietic cell lines; the TIA1/1352R monoclonal antibody reacts with about 90% of CD16+; 50 60% of CD8+; and less than 10% of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T cell clones; activated NK cell clones; and Con activated thymocytes; but not with B lymphocytes or B cell lines. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma; large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
- Host:
- Rabbit
- Immunogen:
- Human bone marrow malignant cells from a non B; non T acute leukemia
- Isotype:
- IgG
- Molecular Weight:
- 40kDa
- Research Area:
- Apoptosis; Autophagy; Nuclear Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122046
