TIA1 (T-Cell-Restricted Intracellular Antigen-1) Antibody
Product Sizes
100 ug
£671.00
7072-MSM1-P1ABX-100UG
About this Product
- SKU:
- 7072-MSM1-P1ABX
- Additional Names:
- Nucleolysin TIA-1 isoform p40 | RNA-binding protein TIA-1 | T-cell-restricted intracellular antigen-1 | p40-TIA-1
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- TIA1/1313
- Clonality:
- Monoclonal
- Extra Details:
- TIA-1 (T-cell intracytoplasmic antigen) is a cytoplasmic granule-associated protein; expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kDa protein thought to be derived from the carboxyl terminus of the 40kDa product by proteolytic processing. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma; large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
- Host:
- Mouse
- Immunogen:
- Recombinant human TIA1 fragment of 102 amino acid residues (aa279-380)
- Isotype:
- IgG2b
- Molecular Weight:
- 40kDa
- Research Area:
- Apoptosis; Autophagy; Nuclear Marker; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122044
