Transglutaminase II (TGM2) Antibody
Product Sizes
100 ug
£671.00
7052-MSM1XX-P1ABX-100UG
About this Product
- SKU:
- 7052-MSM1XX-P1ABX
- Additional Names:
- Erythrocyte transglutaminase | Heart G alpha(h) | Isopeptidase TGM2 | Protein G alpha(h) | Protein-glutamine deamidase TGM2 | Protein-glutamine dopaminyltransferase TGM2 | Protein-glutamine histaminyltransferase TGM2 | Protein-glutamine noradrenalinyltransferase TGM2 | Protein-glutamine serotonyltransferase TGM2 | Tissue transglutaminase | Transglutaminase C | Transglutaminase H | Transglutaminase II | Transglutaminase-2
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- SPM592
- Clonality:
- Monoclonal
- Extra Details:
- Recognizes a 77-85kDa protein; identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved; they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer; is induced by retinoic acid; and appears to be involved in apoptosis. Finally; the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD); a genetic; immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death; signal transduction; drug-resistance; cell growth; endocytosis; insulin secretion; cell adhesion; cataract formation; and wound healing.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TGM2 protein
- Isotype:
- IgG1
- Molecular Weight:
- 77-85kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=122014
