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Antibodies

Recombinant pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein) Antibody

Product Sizes
100 ug
£671.00
7031-RBM4-P1-100UG
About this Product
SKU:
7031-RBM4-P1
Additional Names:
Breast cancer estrogen-inducible protein | PNR-2 | Polypeptide P1.A | Protein pS2
Application:
Immunohistochemistry, Western Blot
translate.label.attr.clone:
TFF1/2969R
Clonality:
Monoclonal
Extra Details:
It recognizes a polypeptide of 6.5kDa; identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds; forming the trefoil motif; or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic; often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa; gastric fluid; goblet cells in the colon and small intestine; and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Host:
Rabbit
Immunogen:
Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCFYPNTIDVPPEEECEF (aa57-84) from the C-terminus of human pS2
Isotype:
IgG
Molecular Weight:
6.5kDa
Research Area:
Signal Transduction
Shipping Conditions:
Blue Ice
Storage Conditions:
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplier:
NeoBiotechnologies
Type:
Antibodies: Monoclonal Antibody