Recombinant pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein) Antibody
Product Sizes
100 ug
£671.00
7031-MSM17-P1-100UG
About this Product
- SKU:
- 7031-MSM17-P1
- Additional Names:
- Breast cancer estrogen-inducible protein | PNR-2 | Polypeptide P1.A | Protein pS2
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- rTFF1/9134
- Clonality:
- Monoclonal
- Extra Details:
- It recognizes a polypeptide of 6.5kDa; identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds; forming the trefoil motif; or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic; often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa; gastric fluid; goblet cells in the colon and small intestine; and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-84) of human TFF1 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 6.5kDa
- Research Area:
- Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=135723
