TFAM / TCF6 (Transcription factor A; mitochondrial) / mtTFA Antibody
Product Sizes
100 ug
£671.00
7019-MSM1-P1-100UG
About this Product
- SKU:
- 7019-MSM1-P1
- Additional Names:
- anscription factor 6-like 1 antibody; Mitochondrial transcription factor 1 antibody; mitochondrial transcription factor A antibody; MtTF1 antibody; mtTFA antibody; TCF 6 antibody; TCF-6 antibody; TCF6 antibody; TCF6L1 antibody; TCF6L2 antibody; TCF6L3 antibody; TFAM antibody; TFAM_HUMAN antibody; Transcription factor 6 antibody; Transcription factor 6 like 2 (mitochondrial transcription factor) antibody; Transcription factor 6 like 2 antibody; Transcription factor 6-like 2 antibody; transcription factor 6-like 3 antibody; Transcription factor A; mitochondrial antibody; Transcription factor A; mitochondrial antibody; Transcription factor A; mitochondrial precursor antibody
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- TFAM/9713
- Clonality:
- Monoclonal
- Extra Details:
- mtTFA (mitochondrial transcription factor A); also known as mtTF1; TFAM; TCF6 (for transcription factor 6-like1); TCF6L2 and tsHMG; is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse; testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy; exercise intolerance and muscle wasting.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human TFAM protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 25kDa
- Research Area:
- Cardiovascular; Epigenetics; Metabolism; Mitochondria Marker; Neuroscience; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=139874
