Transferrin (Early Marker of Oligodendrocytes) Antibody
Product Sizes
100 ug
£671.00
7018-MSM5-P1-100UG
About this Product
- SKU:
- 7018-MSM5-P1
- Additional Names:
- Beta-1 metal-binding globulin | Siderophilin
- Application:
- ELISA, Immunohistochemistry
- translate.label.attr.clone:
- TF/4795
- Clonality:
- Monoclonal
- Extra Details:
- Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf); the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains; each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood; but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes; where transferrin is an early marker of oligodendrocyte differentiation. From the blood; transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR); also designated CD71; through a system of coated pits and vesicles. After Fe release; transferrin is returned to the extracellular medium; where it can be reused. Defects in the transferrin gene results in atransferrinemia; a rare autosomal recessive disorder characterized by microcytic anemia and iron loading.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 311-445) of human TF protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 79kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131932
