TCF7 Antibody
Product Sizes
100 ug
£671.00
6932-MSM1-P1-100UG
About this Product
- SKU:
- 6932-MSM1-P1
- Additional Names:
- T-cell-specific transcription factor 1
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- TCF7/7631
- Clonality:
- Monoclonal
- Extra Details:
- Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1; TLE2; TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa200-400) of human TCF7 protein (exact sequence is proprietary)
- Isotype:
- IgG2
- Molecular Weight:
- 41.6kDa
- Research Area:
- Breast Cancer; Cardiovascular; Developmental Biology; Nuclear Marker; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131906
