Hepatocyte nuclear factor 1 beta (HNF1b) / Transcription Factor 2 (TCF2) Antibody
Product Sizes
100 ug
£671.00
6928-MSM1-P1ABX-100UG
About this Product
- SKU:
- 6928-MSM1-P1ABX
- Additional Names:
- FJHN antibody; Hepatocyte nuclear factor 1 beta antibody; Hepatocyte nuclear factor 1-beta antibody; HNF 1B antibody; HNF 2 antibody; HNF-1-beta antibody; HNF-1B antibody; HNF1 beta antibody; HNF1 homeobox B antibody; HNF1B antibody; HNF1B_HUMAN antibody; HNF1beta antibody; HNF2 antibody; Homeoprotein LF B3 antibody; Homeoprotein LFB3 antibody; HPC11 antibody LF B3 antibody ;LFB3 antibody; MODY 5 antibody; MODY5 antibody TCF 2 antibody; TCF 2 protein antibody; TCF-2 antibody TCF2 antibody; TCF2 protein antibody; Transcription factor 2 antibody; Transcription factor 2 hepatic antibody; Variant hepatic nuclear factor 1 antibody; Variant hepatic nuclear factor antibody; VHNF 1 antibody; vHNF1 antibody
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- HNF1B/9518
- Clonality:
- Monoclonal
- Extra Details:
- HNF-1 (a and b); HNF-3 (a; b and g); HNF-4 (a and g) and HNF-6 compose; in part; a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney; small intestine and thymus. HNF-3a; HNF-3b and HNF-3g regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3a and HNF-3b have also been shown to be involved in gastrulation events such as body axis formation. HNF-4a and HNF-4g have been shown to be important for early embryo development. HNF-4a is expressed in liver; kidney; pancreas; small intestine; testis and colon; and HNF-4g is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3b; which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transcriptional activator for at least 22 other hepatocyte enriched genes; including cytochrome P450 2C13 and a-1 antitrypsin.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human HNF1B protein (exact sequence is proprietary)
- Isotype:
- IgG2a
- Molecular Weight:
- 61kDa
- Research Area:
- Kidney; Pancreatic Cancer; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=143951
