TRBP2 / TARBP2 Antibody
Product Sizes
100 ug
£671.00
6895-MSM1-P1ABX-100UG
About this Product
- SKU:
- 6895-MSM1-P1ABX
- Additional Names:
- TAR RNA-binding protein 2 | Trans-activation-responsive RNA-binding protein
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-TARBP2-1E5
- Clonality:
- Monoclonal
- Extra Details:
- TRBP2; also known as TARBP2 (trans-activation-responsive (HIV-1) RNA binding protein 2); TRBP1 or TRBP; is a nuclear protein that contains three DRBM (double-stranded RNA-binding) domains. TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. The third DRBM motif in the C-terminus of human TRBP2 can interact with and inhibit PKR activity; thereby increasing HIV-1 long terminal repeat (LTR) expression. In addition; TRBP2 functions as a component of a Dicer-containing complex and associates with the catalytic subunit of the RNA-induced silencing complex (RISC); namely eIF2C2. TRBP2 is essential for Dicer stability and the proper assembly of RISC. This suggests that TRBP2; in association with Dicer; plays an important role in the processing of miRNAs (microRNAs).
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human TARBP2 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 45kDa
- Research Area:
- Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121807
