Recombinant STAT6 (Solitary Fibrous Tumor Marker) Antibody
Product Sizes
100 ug
£671.00
6778-RBM4-P1ABX-100UG
About this Product
- SKU:
- 6778-RBM4-P1ABX
- Additional Names:
- IL-4 Stat
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- STAT6/7774R
- Clonality:
- Monoclonal
- Extra Details:
- STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion; formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13; in 55-100% of solitary fibrous tumors; regardless of tumor morphology or anatomical site. By immunohistochemistry; nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges; including meningioma; glioblastoma; gliosarcoma; haemangioblastoma; schwannoma and haemangioma. A recent study by Cheah; et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested; regardless of histology; anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative; demonstrating 100% specificity.
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa647-847) of human STAT6 protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 119kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology; Neuroinflammation; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128919
