STAT5B Antibody
Product Sizes
20 ug
£364.00
6777-MSM1-P0-20UG
About this Product
- SKU:
- 6777-MSM1-P0
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- STAT5B/2611
- Clonality:
- Monoclonal
- Extra Details:
- Signal transducer and activator of transcription 5A (Stat5a) and Stat5b; which share 96% homology; undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors; and then form homo- or heterodimers that translocate to the nucleus; where they initiate transcription. Activation of Stat5a via IL-2; IL-3; IL-7/ GM-CSF; erythropoietin; thrombopoietin and growth hormones influences proliferation; differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2; IL-4; CSF-1 and growth hormones influences TCR signaling; apoptosis; adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human STAT5B protein
- Isotype:
- IgG1
- Molecular Weight:
- 94kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology; Infectious Disease; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121741
