BRCA2 (Breast Marker) Antibody
Product Sizes
100 ug
£671.00
675-MSM1-P1ABX-100UG
About this Product
- SKU:
- 675-MSM1-P1ABX
- Additional Names:
- Fanconi anemia group D1 protein
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- BRCA2/2158
- Clonality:
- Monoclonal
- Extra Details:
- In 1990; a breast cancer susceptibility gene designated BRCA1 was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene; BRCA2 (breast cancer 2; early onset); located on chromosome 13q13.1; also confers a high incidence of breast cancer but; unlike BRCA1; does not confer a substantially elevated risk of ovarian cancer. Both BRCA1 and BRCA2 play a role in the maintainance of genome stability; particularly in the homologous recombination pathway for double-strand DNA repair. BRCA2 is regarded as a tumor suppressor gene; tumors with BRCA2 mutations exhibit loss of heterozygosity (LOH) of the wildtype allele. The protein encoded by the BRCA2 gene contains multiple copies of a 70 amino acid motif called the BRC motif. These motifs effect binding to the Rad51 recombinase; which operates in DNA repair.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 200-500) of human BRCA2 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 390kDa
- Research Area:
- Breast Cancer; Cardiovascular; Infectious Disease; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=134169
