BRAF (V600E Mutant Specific) (Prognostic Marker) Antibody
Product Sizes
100 ug
£671.00
673-MSM2-P1-100UG
About this Product
- SKU:
- 673-MSM2-P1
- Additional Names:
- Proto-oncogene B-Raf | p94 | v-Raf murine sarcoma viral oncogene homolog B1
- Application:
- ELISA
- translate.label.attr.clone:
- V600E/1322
- Clonality:
- Monoclonal
- Extra Details:
- The ÔøΩBRAF ÔøΩgene encodes a cytoplasmic serine-threonine kinase; which initiates the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. The oncogenic mutations in the kinase region of BRAF gene result in constitutive activation of the MAPK signalling pathway; leading to increased cell proliferation; resistance to apoptosis and tumor progression. The most common of all activating BRAF mutations leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The ÔøΩBRAF ÔøΩV600E mutation is an important predictive and prognostic biomarker. The BRAF V600E mutation is detected in approximately 8% of all solid tumours; including 45% of papillary thyroid carcinomas; 40-60% of melanomas; 5-15% of colorectal adenocarcinomas; 35% of serous low grade and borderline ovarian carcinomas; 1-3% of non-small cell lung cancers; and 5-7% of cholangiocarcinomas. ÔøΩFurthermore; the BRAF V600E mutation is found in 100% of hairy cell leukaemia; ÔøΩ54% Erdheim-Chester disease; 38% of Langerhans cell histocytoses ÔøΩand 60% of pleomorphic xanthoastrocytomas. ÔøΩ
- Host:
- Mouse
- Immunogen:
- An eleven amino acid residue long synthetic peptide (aa596-606); corresponding to Cys-GLAT(E)KSRWSG from human BRAF protein. It was conjugated to KLH at the N-terminus.
- Isotype:
- IgG
- Molecular Weight:
- 35kDa (predicted)
- Research Area:
- B Cell Markers; Bladder Cancer; Breast Cancer; Cardiovascular; Colon Cancer; Infectious Disease; MAPK Signaling; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=130551
