BRAF (V600E Mutant Specific) (Prognostic Marker) Antibody
Product Sizes
20 ug
£364.00
673-MSM1-P0-20UG
About this Product
- SKU:
- 673-MSM1-P0
- Additional Names:
- Proto-oncogene B-Raf | p94 | v-Raf murine sarcoma viral oncogene homolog B1
- Application:
- ELISA, Western Blot
- translate.label.attr.clone:
- V600E/1321
- Clonality:
- Monoclonal
- Extra Details:
- The �BRAF �gene encodes a cytoplasmic serine-threonine kinase; which initiates the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. The oncogenic mutations in the kinase region of BRAF gene result in constitutive activation of the MAPK signalling pathway; leading to increased cell proliferation; resistance to apoptosis and tumor progression. The most common of all activating BRAF mutations leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The �BRAF �V600E mutation is an important predictive and prognostic biomarker. The BRAF V600E mutation is detected in approximately 8% of all solid tumours; including 45% of papillary thyroid carcinomas; 40-60% of melanomas; 5-15% of colorectal adenocarcinomas; 35% of serous low grade and borderline ovarian carcinomas; 1-3% of non-small cell lung cancers; and 5-7% of cholangiocarcinomas. �Furthermore; the BRAF V600E mutation is found in 100% of hairy cell leukaemia; �54% Erdheim-Chester disease; 38% of Langerhans cell histocytoses �and 60% of pleomorphic xanthoastrocytomas. �
- Host:
- Mouse
- Immunogen:
- An eleven amino acid residue long synthetic peptide (aa596-606); corresponding to Cys-GLAT(E)KSRWSG from human BRAF protein. It was conjugated to KLH at the N-terminus.
- Isotype:
- IgG1
- Molecular Weight:
- 35kDa (predicted)
- Research Area:
- B Cell Markers; Bladder Cancer; Breast Cancer; Cardiovascular; Colon Cancer; Infectious Disease; MAPK Signaling; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=128376
