SREBP2 (Transcription Factor) Antibody
Product Sizes
100 ug
£671.00
6721-MSM2-P1ABX-100UG
About this Product
- SKU:
- 6721-MSM2-P1ABX
- Additional Names:
- Class D basic helix-loop-helix protein 2 | Sterol regulatory element-binding transcription factor 2
- Application:
- ELISA, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- SREBP2/1580
- Clonality:
- Monoclonal
- Extra Details:
- The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins; thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region; designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted; the element is activated; the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified; including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors; designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SREBF2protein
- Isotype:
- IgG1
- Molecular Weight:
- 68/125kDa
- Research Area:
- Cardiovascular; Developmental Biology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121685
