BRCA1 (Breast Marker) Antibody
Product Sizes
100 ug
£671.00
672-MSM3-P1ABX-100UG
About this Product
- SKU:
- 672-MSM3-P1ABX
- Additional Names:
- RING finger protein 53 | RING-type E3 ubiquitin transferase BRCA1
- Application:
- ELISA
- translate.label.attr.clone:
- BRCA1/2973
- Clonality:
- Monoclonal
- Extra Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability; and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors; DNA damage sensors; and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II; and through the C-terminal domain; also interacts with histone deacetylase complexes. This protein thus plays a role in transcription; DNA repair of double-stranded breaks; and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 445-620) of human BRCA1 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 220kDa
- Research Area:
- Breast Cancer; Cardiovascular; Infectious Disease; Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=127272
