Spectrin beta III (SPTBN2) Antibody
Product Sizes
100 ug
£671.00
6712-MSM5-P1ABX-100UG
About this Product
- SKU:
- 6712-MSM5-P1ABX
- Additional Names:
- Beta-III spectrin | Spinocerebellar ataxia 5 protein
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- SPTBN2/1778
- Clonality:
- Monoclonal
- Extra Details:
- Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers; tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II); four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin 伪 and spectrin 尾 are present in erythrocytes; whereas spectrin 伪 II (also designated fodrin 伪) and spectrin 尾 I (also designated fodrin 尾) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion; but spectrin dimers seem to lack this function. Spectrin 尾 III is highly homologous to both spectrin 尾 I and spectrin 尾 II. Spectrin 尾 III is highly expressed in brain; kidney; pancreas and liver; and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum; where it is found in Purkinje cell soma and dendrites.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa356-475) of human SPTBN2 protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 246kDa
- Research Area:
- Developmental Biology; Immunology; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121651
