Fodrin / Alpha Spectrin II (SPTAN1) / NEAS Antibody
Product Sizes
20 ug
£364.00
6709-MSM4-P0-20UG
About this Product
- SKU:
- 6709-MSM4-P0
- Additional Names:
- Alpha-II spectrin | Fodrin alpha chain | Spectrin; non-erythroid alpha subunit
- Application:
- ELISA
- translate.label.attr.clone:
- SPTAN1/3374
- Clonality:
- Monoclonal
- Extra Details:
- Spectrin; an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane; is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers; composed of nonhomologous α and β chains; which aggregate side-to-side in an antiparallel fashion to form dimers; tetramers; and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes; whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion; but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin α II; a neuronal cytoskeleton protein.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human SPTAN1 protein (around aa2351-2475) (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 240kDa
- Research Area:
- Apoptosis; Autophagy; Cardiovascular; Developmental Biology; Immunology; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=132542
