Spastin Antibody
Product Sizes
100 ug
£671.00
6683-MSM2-P1ABX-100UG
About this Product
- SKU:
- 6683-MSM2-P1ABX
- Additional Names:
- Spastic paraplegia 4 protein
- Application:
- Immunofluorescence, Western Blot
- translate.label.attr.clone:
- Sp 6C6
- Clonality:
- Monoclonal
- Extra Details:
- The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility; membrane trafficking; proteolysis; protein folding and organelle biogenesis. Spastin; a member of the AAA protein family; is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm; where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST; SPG4) cause the most common form of spastic paraplegia 4; an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent; retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40% of all autosomal dominant HSPs.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human Spastin protein.
- Isotype:
- IgG2a
- Molecular Weight:
- 52kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121506
