SPARC / Osteonectin Antibody
Product Sizes
100 ug
£671.00
6678-MSM8-P1-100UG
About this Product
- SKU:
- 6678-MSM8-P1
- Additional Names:
- Basement-membrane protein 40 | Osteonectin | Secreted protein acidic and rich in cysteine
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- OSTN/3758
- Clonality:
- Monoclonal
- Extra Details:
- SPARC (for secreted protein acidic and rich in cysteine) is a phosphorylated; acidic; glycine-rich glycoprotein that is secreted by endothelial cells and is present in large amounts in the parietal endoderm of mouse embryos and in human placenta. It is identical to osteonectin; a protein important to bone calcification that is highly conserved between species. SPARC; which can be selectively expressed by the endothelium in response to certain types of injury; induces rounding in adherent endothelial cells in vitro. It regulates endothelial barrier function through F-Actin-dependent changes in cell shape; coincident with the appearance of intercellular gaps; which provide a paracellular pathway for extravasation of macromolecules.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa1-200) of human SPARC protein (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 38kDa
- Research Area:
- Cardiovascular; Endothelial Cell Marker; Mesenchymal Stem Cell Differentiation; Signal Transduction
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121503
