SP100 Antibody
Product Sizes
20 ug
£364.00
6672-MSM1-P0-20UG
About this Product
- SKU:
- 6672-MSM1-P0
- Additional Names:
- Nuclear dot-associated Sp100 protein | Speckled 100 kDa
- Application:
- ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- PCRP-SP100-1B9
- Clonality:
- Monoclonal
- Extra Details:
- The human SP100 gene encodes an autoantigen that co-localizes with PML and NDP52 in distinct nuclear domains; called nuclear dots (NDs) or ND10 nuclear bodies. Papova-; adeno-; and herpesviruses begin their transcription and DNA-replication at NDs; which play a role in autoimmunity; viral infections and in the etiology of acute promyelocytic leukemia. SP-100 is an interferon inducible protein that has two splice variants. One splice variant contains a highly conserved copy of the DNA-binding high mobility group 1 protein sequence; and thus represents a novel HMG-box protein. This alternatively spliced variant of SP-100 has a unique expression and localization pattern that is distinct from the SP-100 full-length protein. The SP100 protein is covalently modified by the small ubiquitin-related protein SUMO-1. SP-100 contains a functional nuclear localization signal and an ND-targeting region; which overlaps with the SP-100 homodimerization domain.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SP100 protein
- Isotype:
- IgG2b
- Molecular Weight:
- 100.4kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121475
