Recombinant SOX10 (Melanoma Marker) Antibody
Product Sizes
100 ug
£671.00
6663-MSM6-P1ABX-100UG
About this Product
- SKU:
- 6663-MSM6-P1ABX
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- rSOX10/1074
- Clonality:
- Monoclonal
- Extra Details:
- SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain; which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma; including conventional; spindled; and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes; but not by other lymph node components such as dendritic cells; which usually express S100 protein. Commonly used melanoma markers; such as anti-HMB-45 and anti-Melan-A; are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues; it is expressed in Schwann cells; melanocytes; and myoepithelial cells of salivary; bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
- Host:
- Mouse
- Immunogen:
- A recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 49-58kDa
- Research Area:
- Developmental Biology; Neural Stem Cells; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121448
