Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Antibody
Product Sizes
100 ug
£671.00
6647-MSM8-P1ABX-100UG
About this Product
- SKU:
- 6647-MSM8-P1ABX
- Additional Names:
- Superoxide dismutase 1
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- SOD1/4248
- Clonality:
- Monoclonal
- Extra Details:
- Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically; SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions; which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases; including amyotrophic lateral sclerosis (ALS); a neurodegenerative disease characterized by the loss of spinal motor neurons; Down syndrome and Alzheimer s disease. In familial ALS; several mutations in SOD-1 predominate; resulting in the loss of zinc binding; the loss of scavenging activity of SOD-1; and correlate with an increase in neurotoxicity and motor neuron death.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa14-148) of human SOD1 (exact sequence is proprietary)
- Isotype:
- IgG1
- Molecular Weight:
- 16kDa
- Research Area:
- Cardiovascular; Cytokine Signaling; Immunology; Neuroscience; Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121356
