SIGLEC1 / CD169 / Sialoadhesin Antibody
Product Sizes
100 ug
£671.00
6614-MSM1-P1ABX-100UG
About this Product
- SKU:
- 6614-MSM1-P1ABX
- Additional Names:
- Sialic acid-binding Ig-like lectin 1 (Siglec-1)
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- HSn 7D2
- Clonality:
- Monoclonal
- Extra Details:
- Two families of mammalian lectin-like adhesion molecules; the selectins and the sialoadhesins; bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins; designated siglecs or sialoadhesins; are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1;709 amino acid protein; also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant; encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages; sinus-lining cells and reticulum cells.
- Host:
- Mouse
- Immunogen:
- Fc fusion protein containing N-terminal 4 domains of human sialoadhesin.
- Isotype:
- IgG1
- Molecular Weight:
- 185kDa
- Research Area:
- Bladder Cancer; Breast Cancer; Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121296
