SUMO-2/3 Antibody
Product Sizes
100 ug
£671.00
6613-MSM1-P1-100UG
About this Product
- SKU:
- 6613-MSM1-P1
- Additional Names:
- HSMT3 | SMT3 homolog 2 | SUMO-3 | Sentrin-2 | Ubiquitin-like protein SMT3B
- Application:
- Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- SM23/496
- Clonality:
- Monoclonal
- Extra Details:
- This MAb reacts with both SUMO-2 and SUMO-3. The small ubiquitin-related modifier (SUMO) proteins; which include SUMO-1; 2 and 3; belong to the ubiquitin-like protein family. Like ubiquitin; the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also; both utilize the E1; E2 and E3 cascade enzymes for conjugation. However; SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation; whereas sumoylation targets proteins to a variety of cellular processing; including nuclear transport; transcriptional regulation; apoptosis and protein stability. The unconjugated SUMO-1; 2 and 3 proteins localize to the nuclear membrane; nuclear bodies and cytoplasm; respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins; which include MDM2; p53; PML and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1. In addition; SUMO-3 regulates beta-Amyloid generation and may be critical in the onset or progression of Alzheimer's disease.
- Host:
- Mouse
- Immunogen:
- Recombinant human SUMO2 protein
- Isotype:
- IgG1
- Molecular Weight:
- 11-13kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121292
