Integrase interactor 1 (INI-1) / SNF5 / SMARCB1 Antibody
Product Sizes
20 ug
£364.00
6598-MSM4-P0-20UG
About this Product
- SKU:
- 6598-MSM4-P0
- Additional Names:
- BRG1-associated factor 47 | Integrase interactor 1 protein | SNF5 homolog
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SMARCB1/3984
- Clonality:
- Monoclonal
- Extra Details:
- The INI-1 gene; which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex; is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1; that differ by the variable inclusion of amino acids; potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma; supratentorial primitive neuroectodermal tumors (sPNETs) is quite low; and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 65-184) of human SMARCB1 protein (exact sequence is proprietary)
- Isotype:
- IgG2b
- Molecular Weight:
- 47kDa
- Research Area:
- Nuclear Marker; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121266
