Recombinant Smoothelin (Differentiated Smooth Muscle Marker) Antibody
Product Sizes
100 ug
£671.00
6525-RBM1-P1ABX-100UG
About this Product
- SKU:
- 6525-RBM1-P1ABX
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SMTN/2320R
- Clonality:
- Monoclonal
- Extra Details:
- Smoothelin is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. In the vascular system; smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell; smoothelin expression is useful for studying vascular malformation and injury. It is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics; such as myofibroblasts and myoepithelial cells; as well as skeletal and cardiac muscle do not contain smoothelin.To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore; the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this antibody an attractive diagnostic tool. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-); and other mimics (-).
- Host:
- Rabbit
- Immunogen:
- Recombinant full-length human Smoothelin (SMTN) protein
- Isotype:
- IgG
- Molecular Weight:
- 59/110kDa (short/long isoforms|respectively)
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121265
