Recombinant gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody
Product Sizes
100 ug
£671.00
6490-RBM14-P1ABX-100UG
About this Product
- SKU:
- 6490-RBM14-P1ABX
- Additional Names:
- ME20-M | Melanocyte protein Pmel 17 | Melanocytes lineage-specific antigen GP100 | Melanoma-associated ME20 antigen | P1 | P100 | Premelanosome protein | Silver locus protein homolog
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- PMEL/7554R
- Clonality:
- Monoclonal
- Extra Details:
- The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60 64 kDa); which is subsequently cleaved to generate 26kDa and 34 38kDa fragments. By immunohistochemistry; it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi; normal adult melanocytes; and non-melanocytic cells are negative. It does not stain tumor cells of epithelial; lymphoid; glial; or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas; large cell lymphomas; and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This MAb stains fetal and neonatal melanocytes; junctional and blue nevus cells; and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa).
- Host:
- Rabbit
- Immunogen:
- Recombinant fragment (around aa 561-661) of human SILV protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 26-100kDa
- Research Area:
- Immunology; Infectious Disease; Oncology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=152469
