gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody
Product Sizes
100 ug
£671.00
6490-MSM3-P1-100UG
About this Product
- SKU:
- 6490-MSM3-P1
- Additional Names:
- ME20-M | Melanocyte protein Pmel 17 | Melanocytes lineage-specific antigen GP100 | Melanoma-associated ME20 antigen | P1 | P100 | Premelanosome protein | Silver locus protein homolog
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- PMEL/783
- Clonality:
- Monoclonal
- Extra Details:
- The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60-64 kDa); which is subsequently cleaved to generate 26kDa and 34-38kDa fragments. Cytotoxic T lymphocytes (CTL's) recognize melanoma-associated antigens; which belong to three main groups. These groups include tumor-associated testis-specific antigens; melanocyte differentiation antigens and mutated or aberrantly expressed antigens; which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100; also designated ME20-M; ME20-S and PMEL 17; is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues; but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage; which results in a secreted protein.
- Host:
- Mouse
- Immunogen:
- Recombinant human SILV protein
- Isotype:
- IgG1
- Molecular Weight:
- 26-100kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121206
