Recombinant gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker) Antibody
Product Sizes
20 ug
£364.00
6490-MSM11-P0-20UG
About this Product
- SKU:
- 6490-MSM11-P0
- Additional Names:
- ME20-M | Melanocyte protein Pmel 17 | Melanocytes lineage-specific antigen GP100 | Melanoma-associated ME20 antigen | P1 | P100 | Premelanosome protein | Silver locus protein homolog
- Application:
- Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- rPMEL17/6821
- Clonality:
- Monoclonal
- Extra Details:
- The gp100 molecule is a 100kDa glycosylated protein that is cleaved into a small (26kDa) carboxy-terminal fragment and a larger amino- terminal section (60 64 kDa); which is subsequently cleaved to generate 26kDa and 34 38kDa fragments. By immunohistochemistry; it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi; normal adult melanocytes; and non-melanocytic cells are negative. It does not stain tumor cells of epithelial; lymphoid; glial; or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas; large cell lymphomas; and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This MAb stains fetal and neonatal melanocytes; junctional and blue nevus cells; and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa).
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human gp100 protein
- Isotype:
- IgG1
- Molecular Weight:
- 26-100kDa
- Research Area:
- Cardiovascular
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121202
