SET Antibody
Product Sizes
20 ug
£364.00
6418-MSM1-P0-20UG
About this Product
- SKU:
- 6418-MSM1-P0
- Additional Names:
- HLA-DR-associated protein II | Inhibitor of granzyme A-activated DNase | PHAPII | Phosphatase 2A inhibitor I2PP2A | Template-activating factor I
- Application:
- Flow Cytometry, Immunofluorescence, Western Blot
- translate.label.attr.clone:
- PCRP-SET-1C6
- Clonality:
- Monoclonal
- Extra Details:
- Protein phosphatase 2A (PP2A) is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes. Inhibitor 1 of PP2A (I1PP2A) and inhibitor 2 of PP2A (I2PP2A); which share large sequence similarity; are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A. I1PP2A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II. These inhibitor proteins act noncompetitively to selectively inhibit PP2A; but do not affect the phosphatase activity of the related proteins PP1; PP2B and PP2C. The I1PP2A protein is localized to both the cytoplasm and the nucleus. In contrast; I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms tumor cells. Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human SET protein
- Isotype:
- IgG1
- Molecular Weight:
- 39kDa
- Research Area:
- Nuclear Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121116
