VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) Antibody
Product Sizes
20 ug
£364.00
64115-MSM7-P0-20UG
About this Product
- SKU:
- 64115-MSM7-P0
- Additional Names:
- Platelet receptor Gi24 | Stress-induced secreted protein-1 | V-set domain-containing immunoregulatory receptor | V-set immunoregulatory receptor
- Application:
- ELISA, Immunohistochemistry
- translate.label.attr.clone:
- VISTA/3007
- Clonality:
- Monoclonal
- Extra Details:
- VISTA / GI24 is a transmembrane protein expressed in bone; on embryonic stem cells (ESCs); and on tumor cell surfaces. On ESC s; Gi24 appears to positively interact with BMP-4; potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells; Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP; generating a soluble 30kDa extracellular fragment plus a 25-30kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells; T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment). It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human VISTA protein
- Isotype:
- IgG2b
- Molecular Weight:
- 34kDa
- Research Area:
- Immuno Oncology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121115
