Calcineurin B homologous protein 2 / HCC Antigen 520 Antibody
Product Sizes
20 ug
£364.00
63928-MSM1-P0-20UG
About this Product
- SKU:
- 63928-MSM1-P0
- Additional Names:
- Hepatocellular carcinoma-associated antigen 520
- Application:
- Immunofluorescence, Immunohistochemistry, Western Blot
- translate.label.attr.clone:
- CPTC-CHP2-1
- Clonality:
- Monoclonal
- Extra Details:
- CHP2 (calcineurin B homologous protein 2); also known as hepatocellular carcinoma-associated antigen 520; is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1; CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues; CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B; CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
- Host:
- Mouse
- Immunogen:
- Recombinant human full-length CHP2 protein
- Isotype:
- IgG2c
- Molecular Weight:
- 22kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=121082
