PRDM1 / BLIMP-1 Antibody
Product Sizes
20 ug
£364.00
639-MSM1-P0-20UG
About this Product
- SKU:
- 639-MSM1-P0
- Additional Names:
- BLIMP-1 | Beta-interferon gene positive regulatory domain I-binding factor | PR domain-containing protein 1 | Positive regulatory domain I-binding factor 1
- Application:
- Flow Cytometry, Immunofluorescence
- translate.label.attr.clone:
- PCRP-PRDM1-2B9
- Clonality:
- Monoclonal
- Extra Details:
- The development and differentiation of plasma cells; which are terminally differentiated B-cells; are induced by Blimp-1 (B lymphocyte-induced maturation protein; also designated PRDI-BF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone; Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain; represses IFN-b gene transcription and associates with HDAC to recruit it to DNA; thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells; as well as in long-lived; bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage; whereas immature and partially activated cells are eliminated.
- Host:
- Mouse
- Immunogen:
- Recombinant full-length human PRDM1 protein
- Isotype:
- IgG2a
- Molecular Weight:
- 114.8kDa
- Research Area:
- Nuclear Marker; Signal Transduction; Transcription Factors
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=134139
