SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A) Antibody
Product Sizes
100 ug
£671.00
6389-MSM3-P1ABX-100UG
About this Product
- SKU:
- 6389-MSM3-P1ABX
- Additional Names:
- Flavoprotein subunit of complex II
- Application:
- Immunohistochemistry
- translate.label.attr.clone:
- SDHA/7493
- Clonality:
- Monoclonal
- Extra Details:
- In aerobic respiration reactions; succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA); an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction; corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma; while SDHA mutations are associated with juvenile encephalopathy as well as Leigh syndrome; a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited; but not necessarily sporadic; cases of pheochromocytoma.
- Host:
- Mouse
- Immunogen:
- Recombinant fragment (around aa 450-650) of human SDHA protein (exact sequence is proprietary)
- Isotype:
- IgG
- Molecular Weight:
- 70kDa
- Research Area:
- Cardiovascular; Mitochondria Marker
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Supplier:
- NeoBiotechnologies
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:https://www.neobiotechnologies.com/download-datasheet/?PID=131785
